RSV vaccine highly effective in preventing hospitalisation for older people and newborns

• RSV vaccine is around 82% effective in preventing older people being hospitalised with an RSV infection
• Maternal RSV vaccine is 72% effective in preventing hospitalisation for newborns whose mothers are vaccinated more than 14 days before delivery
• Well over half (54.7%) of pregnant women giving birth during March had the RSV vaccine
• By end June, uptake among eligible older people continued to rise with almost two thirds vaccinated (62.9%)

A new UK Health Security Agency study - Effectiveness of RSV Vaccine Against RSV Associated Hospitalisation Among Adults Aged 75-79 years in England - in partnership with Nottingham University Hospitals and other NHS trusts, shows the RSV vaccine provided strong protection for older people, around 82% effective in preventing hospital admissions with RSV infection.

The study also found that the vaccine is highly effective in preventing hospitalisation for older people with a chronic respiratory condition and those living with immunosuppression.

Two new Respiratory Syncytial Virus (RSV) vaccination programmes were introduced to the NHS Vaccination Schedule in September last year; an older adults programme and a maternal programme.

The programme for older adults offers the vaccine to those turning 75, as well as a one-off catch up campaign for all adults aged 75 -79 years.

The maternal vaccination programme is offered to women from 28 weeks of pregnancy to protect newborns, who are at higher risk of severe illness from RSV.

A separate new study - Vaccination in Pregnancy and RSV Hospitalisation in Infants in the UK, led by NHS paediatricians, published in the Lancet Child and Adolescent Health - found that  the maternal RSV vaccine was 72% effective in preventing hospitalisation for infants whose mothers were vaccinated more than 14 days before delivery.

UKHSA has also today published the latest vaccine uptake figures for both RSV programmes:

• Older Adults programme: overall coverage as of 30 June 2025 in the catch-up cohort (adults aged 75 to 79) reached 62.9%, up from the 60.3% reported in March.
• Maternal programme: of the 36,657 women reported as having given birth in March 2025, 20,051 (54.7%) had received an RSV vaccine.
• The maternal coverage varied by ethnic group with the highest coverage reported among the Chinese ethnic group (73.3%) and lowest among Black and Black British Caribbean (26.4%).

Greta Hayward, Consultant Midwife at the UK Health Security Agency, said:

“Having the RSV vaccine during every pregnancy is the best way for women to protect their newborn against RSV, as the vaccine boosts their immune system to produce more antibodies against the virus, and these then pass through the placenta to help protect their baby from the day they are born. RSV infects around 90% of children in their first two years of life.

“The RSV season usually starts in October and while there is no risk-free birth month, babies born in late summer or the autumn are most likely to be admitted to hospital[1]. Hundreds of babies attend Emergency Departments each day for bronchiolitis through most of November and December. That is why it is so important that over the summer pregnant women reaching 28 weeks of pregnancy, ensure they are vaccinated as soon as possible.”

Dr Conall Watson, Immunisation Consultant at the UK Health Security Agency, said:

“The evidence clearly shows the RSV vaccine for pregnant women is highly effective and will give much reassurance to parents, knowing their newborn is protected from birth, when they are at much greater risk from RSV.

“As a parent and health professional I can’t stress enough the importance of getting the RSV vaccine during every pregnancy. We recommend vaccination in week 28 or soon after but if you are later on in your pregnancy and still haven’t had your vaccine please contact your maternity service or GP practice to arrange one.

“RSV can be a particularly serious infection for older people, so this new evidence will also give much reassurance that having the RSV jab will greatly reduce their chances of ending up in hospital.

“While the uptake of the RSV vaccine continues to rise, we want to see every single pregnant woman and eligible older person getting protected. The virus picks up in the autumn, so don’t put if off over the summer - as soon as you reach your 75^th birthday or week 28 of pregnancy get the vaccine for healthy peace of mind.”

UKHSA has published its first RSV Annual Report, which looks back at the 2024 to 2025 RSV season, providing analysis on disease pattern, vaccine uptake and vaccine impact.

The surveillance shows RSV activity started across all UK nations around week 42 of 2024 (week starting 14 October) and peaked around weeks 47 to 49 2024 (18 November to 8 December), before steadily declining and reaching baseline activity around weeks 7 to 8 2025 (10 to 23 February).

The Report also details UKHSA’s analysis from the primary care surveillance, which involves swabbing in around 300 GP Practices in England when a patient presents with an acute respiratory infection (ARI). This found that by age group, the highest RSV positivity (% of laboratory confirmed RSV cases out of total ARI swabs) was observed in children under 5 years; with positivity peaking at 53.1% in week 46 (11-17 November).

Among those aged 75 years and above, the highest RSV positivity rate was 18.5% reported in week 49 (2-8 December).

Surveillance of patients attending hospital emergency departments (ED) in England found that among infants (babies under 1), bronchiolitis peaked in late November. This is the main clinical presentation of infant RSV and RSV is the primary pathogen causing bronchiolitis.

 

[1] Reeves et al 2019, ,Burden of hospital admissions caused by respiratory syncytial virus (RSV) in infants in England: A data linkage modelling study - Journal of Infection